The Effects of Surfactants on the Epimerization of 15(S)-15-Methyl-PGF2
The purpose of the present study is two-fold . It is primarily to test if the currently well accepted kinetic treatment based on Michaelis-Menton kinetics does indeed apply to a case of inhibitory catalysis. This aspect curtails the investigation of the effects of surfactant concentration as well as substrate concentration upon a model system. Secondly, it is to evaluate the general magnitude of inhibitory action in micelle catalysis. Our prime area of interest in this aspect was answering the following question, “Would it be possible to stability a pharmaceutical dosage form by means of micelle formation?” Many examples are known in which micelles are used to catalyze a specific reaction, however, the inhibitory effects of micelles is an area which is basically untouched. The specific acid catalyzed epimerization of l5(S)-15-methyl-PGF2a was chosen to fulfill these two objectives. The reaction presumably occurs through a stable transition state which is formed via the tertiary carbonium ion.