Absorption Characteristics of U-63,287 as Evaluated by In Situ Rat Gut Perfusion
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Authors
Bangs, Mark E.
Issue Date
1984
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Bioavailability refers to the overall rate and extent to which the active form of a drug enters the general
circulation after oral administration. Bioavailability has
been found to depend on many factors, among them the rate of
dissolution of the dosage form, the permeability of the
intestinal mucosa to the drug, the rate of gastric emptying,
intestinal motility, and interactions between the drug and
intestinal contents. In characterizing the absorption of a
drug, experiments are done to determine the region of optimum absorption within the gastrointestinal tract, the
mechanism(s) and kinetics of absorption, and other critical
physiochemical and biological factors influencing
absorption. This project characterizes the absorption in the rat's intestines of U-63,287, an oral antidiabetic drug. The method used to study U-63,287's absorption is a modification
I of an in situ intestinal perfusion technique developed by
Schanker et al.(l958). The studies performed during this project include a comparison of the relative absorption
rates of U-63,287 in three different intestinal segments, a
quantitative analysis of absorption of U-63,287 from the
duodenum into the mesenteric lymph, a study of the relationship between perfusate residence time and intestinal
absorption, and a study of U-63,287 absorption at different pHs.
Description
vi, 68 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.