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dc.contributor.advisorHonohan, Thomas
dc.contributor.authorBooth, David
dc.descriptionvii, 43 p.en_US
dc.description.abstractPlatelet aggregation has been identified as a possible precipitating event in heart attack, stroke and related vascular disorders. A drug which inhibits platelet aggregation may be useful in the treatment and/or prevention of such diseases. Certain prostaglandin free acids and amides have been shown to be potent inhibitors of platelet aggregation. It has also been shown that PG-amides hydrolyze to the free acids in vitro and in vivo. An animal model which possesses hydrolytic capacity similar to the human would be useful in evaluating prostaglandin amides for their potential usefulness in humans. This project studied the hydrolytic capacity of plasma enzymes from humans, monkeys, guinea pigs and rats. 3-oxa- 4,5,6-trinor-inter-rn-phenylene-PGE1-amide was used to measure the in vitro hydrolytic capacity of these animal models.en_US
dc.description.sponsorshipUpjohn Company, Kalamazoo, MI
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Chemistry.;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleThe In Vitro Hydrolysis of 3-oxa-4, 5, 6-trinor-inter-m-phenylene-PGE1-amideen_US

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  • Chemistry Senior Individualized Projects [827]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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