The In Vitro Hydrolysis of 3-oxa-4, 5, 6-trinor-inter-m-phenylene-PGE1-amide
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Authors
Booth, David
Issue Date
1979
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Platelet aggregation has been identified as a possible
precipitating event in heart attack, stroke and related
vascular disorders. A drug which inhibits platelet aggregation
may be useful in the treatment and/or prevention of
such diseases. Certain prostaglandin free acids and amides have been shown to be potent inhibitors of platelet aggregation. It
has also been shown that PG-amides hydrolyze to the free acids in vitro and in vivo. An animal model which possesses hydrolytic capacity similar to the human would be useful in
evaluating prostaglandin amides for their potential usefulness
in humans. This project studied the hydrolytic capacity of plasma enzymes from humans, monkeys, guinea pigs and rats. 3-oxa-
4,5,6-trinor-inter-rn-phenylene-PGE1-amide was used to measure the in vitro hydrolytic capacity of these animal models.
Description
vii, 43 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.