Degradation Products of Streptozocin in Aqueous Saline Solution at pH 4.6
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Authors
Knuth, Mark W.
Issue Date
1979
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Streptozocin, is a broad-spectrum antibacterial agent produced by Streptomyces achromogenus, and an antitumor agent in clinical use for malignant islet cell cancer of the pancreas. It is also used to induce diabetes in laboratory animals for experimental purposes. In 1967, it was noted that
injections of the drug were not always successful in inducing the condition,
and degradation of the drug in solution during storage was suspected. Work
was done by various researchers which indicated that the drug sometimes would
indeed degrade under conditions closely matching the storage conditions, (0.9% aq. NaCl solution, buffered to pH 4.6 with citric acid) but not always.
One degradation product was isolated and characterized, and two or three other
compounds were thought to remain in the reaction mixture, all difficult to
isolate. Several compounds isolated from degradative procedures under various
conditions during the structure determination of streptozocin were used as reference
compounds in this work. This report presents evidence concerning degradation
products of streptozocin in pH 4.6 buffered saline solution which have been isolated and characterized, optimum conditions for the degradative reaction, and miscellaneous data pertaining to the subject.
Description
21 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.