Reactions of 2-Aminooxadiazoles and 2-Aminothiazoles with ß-Keto Esters
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Studies the reactivity of certain heterocyclic amines with dicarbonyl compounds with emphasis on the reactions of 2-amino-S-substituted-1,3,4-thiadiazoles. The reactions of two analogous compounds, 2-amino-5-substituted-l,3,4-oxadiazoles and 2-amino-4-substituted-thiazoles, will be explored. In light of the findings of Lauer and Zenchoff, Okabe, Maekawa, and Taniguchi, and Kornis and Marks, an interest arose to study other bidendate molecules: to determine whether or not they would undergo similar reactions, and, if so, whether the products would be analogous to the thiadiazole series. The first choice of bidendate was the 2-amino-l,3,4-oxadiazole series, where oxygen is substituted in the ring (1) for sulfur; generally, the behaviour of oxygen-sulfur analogs is similar. Upon conclusion of that project, an investigation of the 2-aminothiazoles was started, but only partially completed.