Acylation and Alkylation Reactions of 5-(2, 6-Dialkylphrenyl) Amino-1, 2, 3, 4-Thiatriazoles
Atherton, James P.
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This project explored the steric effect of methyl, ethyl, and isopropyl groups in the two and six positions of the anilino ring on the site of acyl or alkyl group attack. It was hypothesized, that by hindering the 5-amino nitrogen reaction site with bulky alkyl groups in the two and six positions of the anilino ring, alkylation could be directed predominantly to the 4-nitrogen and acylation could be made to occur to some extent on the 4-nitrogen.