A Study of the Alkylating Abilities of 1-(2-Hydroxyethyl)-1-Nitrosourea and 1-Ethyl-1-Nitrosourea
Loading...
Authors
Dowuona, David
Issue Date
1980
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
In this thesis project, we studied two alkylating reagents with
similar structural and chemical properties, 1-{2-hydroxyethyl)-1-nitrosourea (HNU) and l-ethyl-l-nitrosourea (ENU). Since they react
via similar reactive intermediates, it is expected that they would both alkylate DNA to the same extents and at the same sites and have equal carcinogenic potency. It was also proposed that the HNU DNA phosphotriester product would be unstable: while the ENU phosphotriesters would be stable. Accordingly, if DNA reactions and
tumourigenicity were identical for the 2 compounds, the importance of
phosphotriesters in alkylation carcinogenesis would be further cast in doubt. The first part of the proposal, that HNU and ENU. are equicarcinogenic,
has been previously shown. The purpose of this study was to
provide background information to support or refute the proposal of
equal alkylation by ENU and HNU.
Description
31 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.