The Effect of Adriamycin on Respiratory Control in Rat Heart Mitochondria

Abstract

The purpose of this experiment was to monitor the oxidative phosphorylation of preparations of intact mitochondria from heart tissue of both adriamycin-treated and control rats. It was hoped that a link could be made between the cardiotoxic effect of the drug and altered levels of oxidative phosphorylation. If a change in ADP :O ratios was found an attempt would be made to see where adriamycin had its effect on the mechanism of oxidative phosphorylation using various substrates.