The Effect of Adriamycin on Respiratory Control in Rat Heart Mitochondria
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The purpose of this experiment was to monitor the oxidative phosphorylation of preparations of intact mitochondria from heart tissue of both adriamycin-treated and control rats. It was hoped that a link could be made between the cardiotoxic effect of the drug and altered levels of oxidative phosphorylation. If a change in ADP :O ratios was found an attempt would be made to see where adriamycin had its effect on the mechanism of oxidative phosphorylation using various substrates.