Effect of Streptozotocin Diabetes on Thyroid Release in Cultured Thyroid Glands
Edwards, Scott B.
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Evidence has accumulated indicating that thyroid function may be considerably influenced by the endocrine pancreas. It is known that thyroid release is stimulated: by insulin administration but relatively little work has been done investigating the effects of diabetes on thyroid release. The present investigation studies thyroid release in normal, semi-starve, and diabetic mice. Diabetes was induced by a single streptozotocin injection (200 mg/kg body weight). The animals' were maintained on a low iodine diet (LID) and on a regular iodine diet (RID). Using an in vitro technique, cultured thyroid glands of the diabetic animals were found to have no significant difference in thyroid release on either of the diets employed.
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