Partial Synthesis of a Spin-Labeled Nitrosamine
Shimp, Dale R.
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Although many pharmacological studies have shown the ability of nitrosamines to cause tumors, the mechanism of their carcinogenic action has been a topic of debate. The author worked with the National Cancer Institute and the National Institutes of Health to partially synthesize and label such biologically active compounds to spectroscopically observe a labeled molecule interacting with physiological systems and/or biological macromolecules. The interaction of nitrosamines with nucleic acids is thought to be the crucial factor in the carcinogenic action of this family of compounds.