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dc.contributor.advisorCho, Moo J.
dc.contributor.authorForrester, Joseph
dc.descriptioniii, 49 p.en_US
dc.description.abstractPresently, there exists two approaches to prodrug synthesis. The most frequently employed is to synthesize a slew of pro-moieties of a parent drug and then test each one for its effectiveness on an in-vivo system . This random hit and miss approach is grossly inefficient due to the infrequency of finding an effective pro-moiety in the lot. The alternate approach, which is less frequently employed, is to ' predict ' the physiochemical requirements necessary for a particular biological response and transforming them into structural requirements. This approach, due to its systematic nature and conservation of man hours is by far the most appealing. However, there exist formidable difficulties. Namely, a carefully designed prodrug does not always lead to the desired biological activity. To hurdle this barrier, a good background of how biological activity is affected by substituent steric and electronic effects is required. This background is gained through a strong knowledge of enzyme kinetics and mechanisms as they exist in the body . Once the "pure" enzyme system is understood, application of its basic, and sometimes not so basic , rate determinants can be applied to a semi in-vivo system . The deviations of the semi in-vivo or in-vivo system from pure enzyme kinetics can then be characterized . Thus, a firm foundation of the enzyme kinetics of prodrug hydrolysis is required for the eventual prediction of what structural requirementsen_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Chemistry.;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleThe Human Serum Hydrolysis of Paranitro-Phenol Estersen_US

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  • Chemistry Senior Individualized Projects [860]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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