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dc.contributor.advisorCho, Moo J.
dc.contributor.authorSmall, David S., Jr
dc.descriptioniii, 35 p.en_US
dc.description.abstractAll of the experimental evidence accumulated during this project indicates that metronidazole glycinate is a viable prodrug of metronidazole. Its aqueous solubility is more than sufficient for the concentrations desired, the pH of the MGT is not too low for parenteral administration, and the serum hydrolysis of the prodrug is rapid. The only drawback to metronidazole glycinate that can be determined thus far is that it is instable in solution. This can be avoided, however, by developing an easily reconstitutable freeze-dried solid dosage form. Upon reconstitution in a proper diluent, spontaneous hydrolysis will take place, however, there will be sufficient time for administration before metronidazole begins to precipitate out of solution.en_US
dc.description.sponsorshipUpjohn Company, Kalamazoo, MI
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Chemistry.;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleGlycine Ester of Metronidazole as a Water-Soluble Prodrugen_US

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  • Chemistry Senior Individualized Projects [827]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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