Gas-Liquid Chromatography Analysis of Facilitated Monosaccharide Transport across Human Erythrocyte Membranes
Vander Meulen, Timothy C.
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The entity of the cellular membrane has been a matter of great concern. It is believed that only when an appreciable knowledge of the interrelationships of the membrane structure and transport processes is elucidated, disorders such as cancer and heart disease will be controlled and cured. Facilitated transport is one of these processes hoped to be directly related to future curatives. This paper has provided a general discussion of the facilitated transport process in relation to membrane structure models and has distinguished the process from the simple and active forms of transport. It further has attempted to describe a small functional aspect of the process with an examination of the monosaccharide transport system of human erythrocytes and the developement of techniques for monitoring the transport process. Gas-liquid chromatographic methods were found to be the most convenient and accurate for an examination of the transport behavior of two monosaccharide diastereoisomers, beta-methyl-L-arabinoside and betamethyl-D-xyloside.