Selected Studies on the Reduction Potential of Hydroperoxides through Cyclic Voltammetry
Clune, Michael J.
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The cytochrome P-4S0-dependent monooxygenase system is responsible for the removal of toxic substances from the body. Unfortunately, this enzymatic pathway is also responsible for the conversion of several relatively inert chemicals into potent carcinogens and mutagens. Recent studies concerning the environmental carcinogen Benzo Pyrene indicate that this compound is converted into a mutanogenic diol-epoxide by the cytochrome P-450 monooxygenase system. The conversion, carried out through a chemical pathway, indicates that hydroperoxides are essential to the formation of the diol-epoxide. Rate of epoxidation studies demonstrate differences among various fatty acid hydroperoxides. This study was designed to investigate a kinetic explanation for this phenomenon through a determination of the reduction potential for several hydroperoxides.