Consequences of the Warburg Effect: Hypoxia Induction of Hypoxia Inducible Factor and New Avenues for Cancer Therapeutics.
Sasinowski, April M.
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German biochemist, Otto Warburg, through his study of the glycolytic pathway in malignant cells, proposed a theory of how cancer cells originate and his further research in the characterization of cancer cells became known as the Warburg Effect (7). Warburg's original argument that glycolysisis greatly enhanced in cancer probably relates to increased proliferation rather than malignanttransformation per se (22). However, shedding new light into this pathway and how malignant cells endure lowered oxygen holds promising anticancer agents in the future that inhibit anaerobic glycolysis.
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