Physical Characterization of Semisolid Topical Formulations
Clay, Megan E.
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Currently semisolid topical formulation development is a subjective process. The central goal of my Senior Individualized Project was todevelop objective ways to evaluate creams, assisting a formulator inquickly creating an effective and useful cream. Thirty-one creams involving various oil phases, surfactants, and methods of manufacture were characterized using appropriate instrumentation. This instrumentation included a Lumifuge®, differential scanning calorimeter, rheometer, and two different probes on a texture analyzer.The results indicate that increasingthe viscosity of the oil phase inthe cream, through the addition of a waxy material which increases the melting point ofthe oil/wax mixture, makes a cream feel and look richer and thicker. The rheology is able to detect this change in the thickness of the cream as an increase in the elastic component (storage modulus, G'). The texture analyzer was less reliable at quantifying the changes in the physical properties inthe creams. The choice of surfactant type and surfactant amount had more subtle effects on the physical properties of the creams which were not clearly correlated with either the rheology orthe texture analyzer results; hence, additional work is needed to find an appropriate analytical method for quantifying theeffect that surfactant type and amount has on the organoleptic properties of a cream formulation.