Structure-Activity Studies Of Somatostatin Agonist And Antagonist Analogs
Hsi, Eric D.
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The objective of this research project was to synthesize new cyclic SRIF analogs possibly exhibiting superagonistic or antagonistic effects on SRIF receptors. The structures of these new analogs were based on information provided in previous structure-activity studies. The SRIF analogs were synthesized via a combination of solid- and solution-phase chemistry. The potency of each new SRIF analog was determined by radioimmunoassay of GH secretion on GRF stimulated bovine pituitary cell cultures in vitro.If you are not a current K College student, faculty, or staff member, email email@example.com to request access to this SIP.