Synthesis and Characterization of P-Iodophenyldodecanoic Acid, A Potential Myocardial Imaging Agent
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Methods were developed for the synthesis of fatty acid analogs bearing iodophenyl moieties at the terminal position. The syntheses of w-(p-iodophenyl) dodecanoic acid and its corresponding 2-palmitol-l,3- disubstituted triglyceride were successfully performed. These agents upon radiolabeling could have potential use for evaluation of regional myocardial fatty acid metabolism. The radioiodinated triglyceride analog was synthesized to ascertain if such analogs could serve as substrates for lipoprotein lipase, thereby delivering radiolabled free fatty acids to myocardial cells upon in vivo hydrolysis.If you are not a current K College student, faculty, or staff member, email email@example.com to request access to this SIP.