The Role of Surface Activity in Tissue Damage as Implied in Pain Upon Intramuscular Injection
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Authors
Buckley, John D.
Issue Date
1985
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The problem of pain upon intramuscular (IM) injection
can be broken down into two categories: that caused by the
syringe penetrating the muscle tissue, and that caused by
the nature of the drug administered. The former is
instantaneous, very temporary, and relatively well
tolerated. Any long-lasting pain that may cause irritation
or inflammation is caused by the latter. It is virtually
unknown what physico - chemical properties of drug
substances, aside from nonphysiological pH and tonicity,
cause pain. This study tests a hypothesis that the surface
activity of a drug substance plays a major role in pain upon
IM injection. Since pain is such a subjective entity, we
use tissue damage and hemolysis as a indication of pain. In this study, tissue damage in rabbit muscle and
hemolysis caused by the sodium n-alkyl sulfonate solutions
were compared to the surface tension of the solutions.
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Description
v, 34 p.
Citation
Publisher
Kalamazoo College
License
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