The Role of Surface Activity in Tissue Damage as Implied in Pain Upon Intramuscular Injection
Buckley, John D.
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The problem of pain upon intramuscular (IM) injection can be broken down into two categories: that caused by the syringe penetrating the muscle tissue, and that caused by the nature of the drug administered. The former is instantaneous, very temporary, and relatively well tolerated. Any long-lasting pain that may cause irritation or inflammation is caused by the latter. It is virtually unknown what physico - chemical properties of drug substances, aside from nonphysiological pH and tonicity, cause pain. This study tests a hypothesis that the surface activity of a drug substance plays a major role in pain upon IM injection. Since pain is such a subjective entity, we use tissue damage and hemolysis as a indication of pain. In this study, tissue damage in rabbit muscle and hemolysis caused by the sodium n-alkyl sulfonate solutions were compared to the surface tension of the solutions.If you are not a current K College student, faculty, or staff member, email email@example.com to request access to this SIP.