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dc.contributor.advisorTownsend, Leroy B.
dc.contributor.authorPillote, Katherine E.
dc.descriptioniii, 42 p.en_US
dc.description.abstractConsiderable interest has been generated in the development of PNP inhibitors due to the recent characterization of a genetic disease by Gilbert and colleagues in 1975, in which the patient exhibited severe lymphopenia ( a lack of white blood cells ), deficiency of cellular immunity and a complete lack of PNP activity. The association of a deficiency of PNP activity with T-cell lymphopenia suggests that a PNP inhibitor may be potentially useful in the treatment of T-cell leukemia, supression of host versus graph response, and autoimmune disease without destroying the patient's humoral immunity.en_US
dc.description.abstractIf you are not a current K College student, faculty, or staff member, email to request access to this SIP.
dc.description.sponsorshipMedicinal Chemistry Department. University of Michigan.
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Chemistry.
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleSynthesis and Characterization of 8 - Amino - 9 - Phenethylguanine, An Inhibitor of Purine Nucleoside Phosphorylaseen_US

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  • Chemistry Senior Individualized Projects [860]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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