Oxidative Metabolism of Acetylenic Monoamine Oxidase Inhibitors by Rat Liver Microsomes
Rolain, Mark Allen
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The oxidative metabolism of three known monoamine oxidase inhibitors: deprenyl, pargyline, and clorgyline, was compared with the metabolism of benzphetamine by the hepatic cytochrome P-450 system. Work was also done to see if these drugs are substrates for a particular cytochrome P-450 isoenzyme; in particular the P-448 and P-450 isoenzymes were tested. The final part of this project dealt with testing these drugs for their capacity to irreversibly inhibit, or more specifically, to be mechanism-based inactivators, of cytochrome P-450 oxidations in liver microsomes.If you are not a current K College student, faculty, or staff member, email email@example.com to request access to this SIP.