Oxidative Metabolism of Acetylenic Monoamine Oxidase Inhibitors by Rat Liver Microsomes
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Authors
Rolain, Mark Allen
Issue Date
1985
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The oxidative metabolism of three known
monoamine oxidase inhibitors: deprenyl, pargyline,
and clorgyline, was compared with the metabolism of
benzphetamine by the hepatic cytochrome P-450
system. Work was also done to see if these drugs
are substrates for a particular cytochrome P-450
isoenzyme; in particular the P-448 and P-450
isoenzymes were tested. The final part of this
project dealt with testing these drugs for their
capacity to irreversibly inhibit, or more
specifically, to be mechanism-based inactivators, of
cytochrome P-450 oxidations in liver microsomes.
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Description
iv, 37 p.
Citation
Publisher
Kalamazoo College
License
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