The formation of Anilines from coupling of Saccharin and Arylboronic Acids using [Cu(OH)L]2Cl2 Catalyst Under Mild Conditions
Abstract
The formation of tertiary anilines is of interest because of the application for
medicinal and industrial synthesis. Existing work demonstrated that the use of a copper
hydroxide catalyst paired with a bidentate ligand had been successful in coupling
arylboronic acid to imidazole to produce tertiary anilines. A new test for this method in
binding arylboronic acids to saccharin to form tertiary amines would be conducted by
optimizing the bidentate ligand used in copper catalyst. After success with the initial
subsitution using phenylboronic acid, substsitution with more complex arylboronic acids
is attempted with mixed results. Further optimization of the process is required for this
method to reach its potential, particularly the conditions surrounding the preparation and
conditions of the catalyst.