Correlation Investigation of Granule Moisture Content, Dissolution, and Calorimetry: Methodology and Experimentation
Radspieler, Cindy K.
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The ultimate goal of the project was to reaffirm that there was a correlation between rate of dissolution and water content of dried granules and to begin to answer the question why this is true on a microscopic level. Steps leading to this goal can be stated as a set of hypotheses. Low water content granules are more friable (break easier) than high water content granules. Therefore, crushed granules with low water content are more friable and have greater surface area than an identical quantity of crushed, high water content dried granules. Therefore, the energy released during immersion is higher and or faster for low water content granules in comparison to the energy released for high water content granules. Therefore, low water content granules may dissolve more rapidly than granules with higher water content in dissolution media.