Browsing by Author "Kailing, Tim"

BKM120, a Novel PI3K Inhibitor, Promotes Medulloblastoma Cell Death Through the Prevention of Akt Phosphorylation and Activation of Apoptotic Pathways.

Voydanoff, Austin P. (Kalamazoo College, 2015)

Medulloblastoma is the most common malignant pediatric brain tumor, and is fatal in 30% of cases. Traditional treatment of medulloblastoma consists of surgical resection followed by chemotherapy and radiation. However, for ...

Copy number variation of barley CBF genes at Frost Resistance-H2 is associated with levels of freezing tolerance

Lathrop, Bonnie A. (Kalamazoo College, 2012)

Following barley‟s domestication in the Fertile Crescent, genes controlling freezing tolerance, winter hardiness and vernalization may have incurred alterations. Freezing tolerance allows for plant survival over winter and ...

Endurance Exercise and Effects on Mobility and Cardiac Healthspan in Drosophila

Daniels, James P. (Kalamazoo College, 2013)

Endurance exercise slows age-related functional decline and alters the metabolic health of an organism. Endurance training leads to remodeling events in both cardiac and skeletal muscle. However, the genetic factors ...

Exploring Differences in Fear Conditioning in Post-Traumatic Stress Disorder

Job, Lara (Kalamazoo College, 2015)

A characteristic commonly found in post-traumatic stress disorder (PTSD) is an inability to inhibit fear even when no genuine threat is present. Those who develop PTSD after a traumatic experience generally exhibit stronger ...

Forbaceous Plants as a Potential Feedstock for Cellulosic Ethanol Production: An Exploration of Composition, Recalcitrance, and Inhibition of Lignocellulosic Biomass Deconstruction

Angelos, Evan R. (Kalamazoo College, 2013)

The reduction of petroleum consumption and the associated negative environmental impacts is becoming increasingly important. One method of reduction is the development of plant based ethanol for fuel use. First generation ...

Genotype Meets Phenotype: Correlating Genetic Changes in Viral Hemorrhagic Septicemia Virus Type IVb with Changes in Virulence in Round Gobies

Imanse, Sierra M. (Kalamazoo College, 2013)

Viral hemorrhagic septicemia virus (VHSV) is an aquatic rhabdovirus first recognized in farmed rainbow trout in Denmark. Recently, a mutated genotype of this virus, type IVb, was dis-covered in the Laurentian Great Lakes ...

In-Vitro Testing of Rituximab in Combination with 2-CdA on Different Lymphoma Infected Cell Lines

Liddane, Allison L. (Kalamazoo College, 2013)

Non-Hodgkin's Lymphoma (NHL) is the most common form of the lymphomas. Each form of lymphoma has different biological behaviors and characteristics. Rituximab (Rtxn) is the drug used most commonly in the treatment of ...

An Inside Scoop on the Booming Industry of Protein Powders : A Literature Review

Arora, Simone A. (Kalamazoo, Mich. : Kalamazoo College., 2015)

Relying more and more on supplements for physique support and control, athletes and bodybuilders look heavily toward protein powders. Not only do protein powders supply protein, they contain high amounts of essential amino ...

Modeling Chagas Disease Prevalence in Vector Population Based on Host Species Diversity Using a Deterministic Model

Cabrera, Carolina (Kalamazoo College, 2014)

Models have been used to study transmission dynamics for over 100 years, earlier than even the Ross model in the early 1900's. The modeling of multihost, vector-borne pathogens such as West Nile virus and Lyme disease has ...

Motion Detection Pathway Search: Investigation of ON Bipolar Cell Subtypes that provide Synaptic Inputs to Starburst Amacrine Cells in the Mouse Retina

Patel, Veeral (Kalamazoo College, 2015)

The visual system utilizes parallel processing to simultaneously process multiple aspects – shape, color, textures, motion, etc. – of an external target by means of different pathways. Bipolar cells (BC) – transmit information ...

The Nephroprotective Effects of Sildenafil Citrate Against Contrast Induced Nephropathy : Assessing Efficacy and Determining Appropriate Dosage in Rabbits

Carey, Edward Grant (Kalamazoo College, 2014)

Contrast induced nephropathy (CIN) is a clinical condition often exhibited by patients undergoing cardiovascular procedures requiring the visualization of blood vessels. To enhance the visibility of blood vessels, radiocontrast ...

Predictors of Successful Revascularization of Chronic Total Occlusions in Superficial Femoral Arterial Lesions with Re-Entry Devices

Zughaib, Marc (Kalamazoo College, 2013)

Objective: To evaluate the relevance of traditional predictors of technical success of percutaneous revascularization of chronic total occlusions (CTOs) in the superficial femoral artery (SFA) with the aid of reentry devices ...

Preliminary Evidence for the Effectiveness of a Community-based Exercise Intervention for Improving Symptoms of Parkinson’s Disease

Timm, Karen J. (Kalamazoo College, 2015)

Parkinson’s disease (PD) is a common progressive disease in which patients gradually lose brain cells that rely on the neurotransmitter dopamine. Currently, there is no known cure for the disease. While several drug and ...